Expression profiling analysis of mouse E10.5 Magoh mutant brain cortices

ABSTRACT: Human brain structure and size requires regulated division of neural stem cells (NSCs). NSCs undergo precise divisions to self-renew and to produce intermediate neural progenitors (INPs) and neurons. The factors that regulate NSC divisions remain poorly understood, as do mechanistic explanations of how aberrant NSC division causes reduced brain size, as seen in microcephaly. Here we demonstrate that Magoh, a component of the core exon junction complex (EJC) that binds spliced RNA, controls cerebral cortical size by regulating NSC division. Magoh haploinsufficiency causes microcephaly due to INP depletion, neuronal apoptosis, and improper mitotic spindle orientation. Defective mitosis underlies these phenotypes as depletion of EJC components disrupts mitotic spindle integrity, chromosome n

ORGANISM(S): Mus musculus

SUBMITTER: Tarran Pierfelice 

PROVIDER: E-GEOD-19168 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress