PARP1 and Salmonella

ABSTRACT: BACKGROUND & AIMS: The immune system comprises an innate and an adaptive immune response to combat pathogenic agents. The human enteropathogen Salmonella enterica serovar Typhimurium invades the intestinal mucosa and triggers an early innate pro-inflammatory host gene response, which results in diarrheal disease. Several host factors are involved in the acute early response to Salmonella infection. Transcription factors and transcription co-regulators have an especially important function, because they are required for the expression and synthesis of pro-inflammatory cytokines, chemokines and adhesion molecules. A central transcription factor involved in inflammation is NF-κB, which requires the nuclear protein PARP1 as co-factor for the expression of some of its target genes. Here, we i

ORGANISM(S): Mus musculus

SUBMITTER: Hubert Rehrauer 

PROVIDER: E-GEOD-19174 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress