Foxa2 programs Th2-cell mediated innate immunity in the developing lung.

ABSTRACT: Deletion of the gene encoding Foxa2, a winged helix transcription factor selectively expressed in respiratory epithelial cells, caused spontaneous pulmonary eosinophilic inflammation and goblet cell metaplasia. Loss of Foxa2 induced the recruitment and activation of myeloid dendritic cells (mDCs) and Th2 cells in the lung, and was associated with the increased production of T helper 2 (Th2) cytokines and chemokines. mRNA microarray analysis demonstrated that deletion of Foxa2 induced the expression of a number of mRNAs regulating pulmonary dendritic cell activation, Th2 mediated inflammation, and goblet cell differentiation. The spontaneous pulmonary inflammation and goblet cell metaplasia caused by loss of Foxa2 was inhibited by treatment of newborn Foxa2â??/â?? mice with monoclonal IL

ORGANISM(S): Mus musculus

SUBMITTER: Jeffrey Whitsett 

PROVIDER: E-GEOD-19204 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress