Progranulin A mediated MET signalling is essential for liver morphogenesis in zebrafish

ABSTRACT: Regulation of embryonic liver growth remains largely elusive. Progranulin has been discussed in pathological liver growth; however, the functional role of Pgrn in embryonic liver growth has never been addressed. Knockdown of GrnA, the orthologue of mammalian pgrn in zebrafish, displayed a deficient hepatic outgrowth during hepatogenesis. Expression profiles manifested that pgrn-deficiency impaired hepatogenesis associated with dysregulation of Met signaling. Pgrn regulates hepatic expression of Met was further verified in vitro and in vivo. These results indicate that Pgrn is a novel factor required for embryonic hepatic outgrowth and reveal a novel link between Pgrn and Met signaling. To explore the GrnA induced genomic responses during hepatic outgrowth, mRNA expression profiles wer

ORGANISM(S): Danio rerio

SUBMITTER: Yen-Hsing Li 

PROVIDER: E-GEOD-19211 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress