Genes Differentially Expressed as a result of Candida albicans SC5314 biofilms exposure to 10b

ABSTRACT: Biomaterial infections are an increasingly alarming problem, and because of their intrinsic recalcitrance to conventional therapy, a new class of antifungal drugs must be explored. 10b, a 2-aminotetralin derivate, was synthesized as a novel chemical structural antifungal agent and exibited strong anti-biofilm activity. To further investigate the action mechanism, we used microarray analysis to investigate the genes expression profiles of C. albicans biofilms treated or untreated with 10b and found 150 genes were differentially expressed. Of them, 69 showed a decrease in expression and 81 showed an increase in expression -10 differentially expressed genes related to biofilm formation, Filamentous or hypha growth. A gene related to specifically hydrolyzing β-1, 3 glucan was significantly in

ORGANISM(S): Candida albicans

SUBMITTER: Rongmei Liang 

PROVIDER: E-GEOD-19226 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress