Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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KKTa_isolated glomeruli

ABSTRACT: High dietary fat intake is a major risk factor for the development of obesity, which is frequently associated with diabetes. To identify genes involved in diabetic nephropathy, GeneChip Expression Analysis was employed to survey the glomerular gene expression profile in diabetic KK/Ta mice fed with a high-fat diet (HFD). Isolated glomeruli from three 20-week-old KK/Ta mice fed with HFD (HFD group) or a normal fat diet (Chow group) were dissected. Total RNA was extracted and labeled for hybridization using the Affymetrix GeneChip Mouse Genome 430 2.0 Array. The gene expression profile was compared between the HFD and Chow groups using GeneSpring 7.3.1 software.

ORGANISM(S): Mus musculus

SUBMITTER: Maki Murakoshi 

PROVIDER: E-GEOD-19251 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Mindin: a novel marker for podocyte injury in diabetic nephropathy.

Murakoshi Maki M   Tanimoto Mitsuo M   Gohda Tomohito T   Hagiwara Shinji S   Takagi Miyuki M   Horikoshi Satoshi S   Tomino Yasuhiko Y  

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20101122 7

<h4>Background</h4>GeneChip Expression Analysis was employed to survey the glomerular gene expression profile in a type 2 diabetes (T2D) model of KK/Ta mice fed with a high-calorie diet (HC), and we focused on the role of mindin (also called spondin 2), whose expression is upregulated by HC.<h4>Methods</h4>Isolated glomeruli from three 20-week-old KK/Ta mice fed with HC or a standard diet (SD) were dissected. Total RNA was extracted and labelled for hybridization using the Affymetrix GeneChip Mo  ...[more]

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