Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of rat astrocytes in culture and from human optic nerve to identify acutely expressed genes during CNS injury and their expression in cultured astrocytes

ABSTRACT: A robust set of CNS transcript changes was defined by comparing microarray data that describe the injury response of the rat retina [Vazquez-Chona et al., IOVS 2004; GSE1001], brain [Matzilevich et al., J Neurosci Res 2002; GSE1911], and spinal cord [Di Giovanni et al., Ann Neurol 2003; GDS63]. We determined the CNS injury genes that were expressed in cultured astrocytes from rat cortex [GSM34300] and from human optic nerve head [Yang et al., Physiol Genomics 2004; GDS532].

ORGANISM(S): Homo sapiens

SUBMITTER: Eldon Geisert 

PROVIDER: E-GEOD-1928 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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<h4>Purpose</h4>The present study defines genomic loci underlying coordinate changes in gene expression following retinal injury.<h4>Methods</h4>A group of acute phase genes expressed in diverse nervous system tissues was defined by combining microarray results from injury studies from rat retina, brain, and spinal cord. Genomic loci regulating the brain expression of acute phase genes were identified using a panel of BXD recombinant inbred (RI) mouse strains. Candidate upstream regulators withi  ...[more]

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