ATM-dependent Transcriptional Responses to 1.5 Gy Gamma Radiation in Human Lymphocytes

ABSTRACT: Ataxia telangiectasia (AT) is an autosomal recessive disorder characterized by neuronal degeneration, telangiectasias, acute cancer predisposition, and hypersensitivity to ionizing radiation (IR). The gene defective in AT, ATM (for AT-mutated), encodes a protein, pATM that has been found to have IR-inducible kinase activity. Cells from individuals with AT exhibit severely attenuated cell cycle checkpoints in response to gamma radiation exposure. pATM has been hypothesized to act as part of a complex that senses DNA damage, in particular, DNA double strand breaks. We are studying the pATM-dependent gene expression responses to a dose of 1.5 Gy radiation in lymphoblastoid cell lines from multiple individuals with either wild type or mutated ATM. The gene expression analyses were perform

ORGANISM(S): Homo sapiens

SUBMITTER: NIEHS Microarray Core 

PROVIDER: E-GEOD-19287 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress