Expression profile of the M-bM-^@M-^\heat-inducible N-degronM-bM-^@M-^] of Nab2 (nab2-td)

ABSTRACT: Gene expression in eukaryotes is an essential process that includes transcription, pre-RNA processing and RNA export. All these steps are coupled and normally, any failure in one step affects the other steps and could cause nuclear mRNA retention. One important player in this interface is the poly(A)-RNA binding protein Nab2, which regulates the poly(A)-tail length of mRNAs protecting their 3M-bM-^@M-^Y-ends from a second round of polyadenylation and facilitating their nucleo-cytoplasmic export. Interestingly, here we show that Nab2 has additional roles in mRNA transcription elongation, tRNA metabolism and rRNA export. We use Genome-wide analysis of expression of a conditional degron nab2 mutant that allows the depletion of the protein in 15 minutes, to demosntrate that the role of Nab2 in

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Cristina GonzM-CM-!lez-Aguilera 

PROVIDER: E-GEOD-19302 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress