Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair-1
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Minoru Ko
PROVIDER: E-GEOD-19309 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair.
Cui Chang-Yi CY Kunisada Makoto M Piao Yulan Y Childress Victoria V Ko Minoru S H MS Schlessinger David D
PloS one 20100401 4
The mouse hair coat comprises protective "primary" and thermo-regulatory "secondary" hairs. Primary hair formation is ectodysplasin (Eda) dependent, but it has been puzzling that Tabby (Eda(-/y)) mice still make secondary hair. We report that Dickkopf 4 (Dkk4), a Wnt antagonist, affects an auxiliary pathway for Eda-independent development of secondary hair. A Dkk4 transgene in wild-type mice had no effect on primary hair, but secondary hairs were severely malformed. Dkk4 action on secondary hair ...[more]
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