Global transcriptional response of macrophage-like THP-1 cells

ABSTRACT: Shiga toxins (Stxs) are bacterial cytotoxins produced by the enteric pathogens Shigella dysenteriae serotype 1 and some serotypes of Escherichia coli that cause bacillary dysentery and hemorrhagic colitis, respectively. To date, approaches to studying the capacity of Stxs to alter gene expression in intoxicated cells have been limited to individual genes. However, it is known that many of the signaling pathways activated by Stxs regulate the expression of multiple genes in mammalian cells. To expand the scope of analysis of gene expression and to better understand the underlying mechanisms for the various effects of Stxs on cell functions, we carried out comparative microarray analyses to characterize the global transcriptional response of human macrophage-like THP-1 cells to Shiga toxin t

ORGANISM(S): Homo sapiens

SUBMITTER: Dinorah Leyva-Illades 

PROVIDER: E-GEOD-19315 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress