Copy Number Abnormalities in Sporadic Canine Colorectal Cancers

ABSTRACT: Human colorectal cancer (CRC) is one of the better-understood systems for studying the genetics of cancer initiation and progression. To develop a cross-species comparison strategy for identifying CRC causative gene or genomic alterations, we performed array comparative genomic hybridization (aCGH) to investigate copy number abnormalities (CNAs), one of the most prominent lesion types reported for human CRCs, in 10 spontaneously occurring canine CRCs. The results revealed for the first time a strong degree of genetic homology between sporadic canine and human CRCs. First, we saw that between 5 and 22% of the canine genome was amplified/deleted in these tumors, and that, reminiscent of human CRCs, the total altered sequences directly correlated to the tumor’s progression stage, origin, an

ORGANISM(S): Canis lupus familiaris

SUBMITTER: Shoshona Le 

PROVIDER: E-GEOD-19318 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress