Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS)

ABSTRACT: Gene expression profiling has been performed on motor cortex and spinal cord homogenates and of sporadic ALS cases and controls, to identify genes and pathways differentially expressed in ALS. More recent studies have combined the use of laser capture microdissection (LCM) with gene expression profiling to isolate the motor neurons from the surrounding cells, such as microglia and astrocytes, in order to determine those genes differentially expressed in the vulnerable cell population – i.e. motor neuron. The aim of this study was to determine the gene expression profiles from a small subset of cases which all carry mutations in the CHMP2B gene. These mutations have been found to be associated with the lower motor neuron dominant variant of ALS. Expression profiles from isolated motor neu

ORGANISM(S): Homo sapiens

SUBMITTER: Janine Kirby 

PROVIDER: E-GEOD-19332 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress