Altered gene expression in normal breast and ovarian epithelial cells from BRCA1 and BRCA2 mutation carriers

ABSTRACT: Early genetic changes during cancer initiation may provide targets for agents that delay, or even prevent, cancer. We hypothesized that cells bearing a single inherited “hit” in a tumor suppressor gene express an altered mRNA repertoire that may identify targets for measures that could delay or even prevent progression to carcinoma. Here, we report on the transcriptomes of primary breast and ovarian epithelial cells cultured from BRCA1 and BRCA2 mutation-carriers and controls. Our comparison analyses identified multiple changes in gene expression, in both tissues for both mutations that were independently validated by real-time RT-PCR analysis. Several of the differentially expressed genes had been previously proposed as cancer markers including, mammaglobin in breast cancer and se

ORGANISM(S): Homo sapiens

SUBMITTER: Alfred Knudson Jr 

PROVIDER: E-GEOD-19383 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress