Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS

ABSTRACT: The progressive loss of CNS myelin in patients with multiple sclerosis (MS) has been proposed to result from the combined effects of damage to oligodendrocytes and failure of remyelination. A common feature of demyelinated lesions is the presence of oligodendrocyte precursors (OLPs) blocked at a premyelinating stage. However, the mechanistic basis for inhibition of myelin repair is incompletely understood. To identify novel regulators of OLP differentiation, potentially dysregulated during repair, we performed a genome-wide screen of 1040 transcription factor-encoding genes expressed in remyelinating rodent lesions. We report that M-bM-^HM-<50 transcription factor-encoding genes show dynamic expression during repair and that expression of the Wnt pathway mediator Tcf4 (aka Tcf7l2) within O

ORGANISM(S): Mus musculus

SUBMITTER: Lohith Madireddy 

PROVIDER: E-GEOD-19403 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress