Predictive Gene Signatures as Strong Prognostic Indicators of the Effectiveness of BCG Immunotherapy

ABSTRACT: Full title: Predictive Gene Signatures as Strong Prognostic Indicators of the Effectiveness of Bacillus Calmetteâ??Guérin (BCG) Immunotherapy in Primary pT1 Bladder Cancers Intravesical BCG immunotherapy is effective in prevention of recurrence and progression in many cases of non-muscle invasive bladder cancer, but many patients fail to respond. This study identified predictive gene signatures in primary pT1 bladder cancer with BCG immunotherapy. Fourty-Eight patients with primary pT1 bladder cancer treated with BCG immunotherapy were used. Microarray gene expression analysis of the 48 primary bladder cancers was carried out. Predictive gene signatures were individually selected based on the recurrence and progression status. Among 43,148 unique genes, 424 and 287 candidate predictive ge

ORGANISM(S): Homo sapiens

SUBMITTER: Sun-Hee Leem 

PROVIDER: E-GEOD-19423 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress