Transcription profiling of CD34+ cells from the bone marrow of Myelodysplastic syndrome patients and healthy controls

ABSTRACT: In order to gain insight into the molecular pathogenesis of the myelodysplastic syndromes (MDS), we performed global gene expression profiling and pathway analysis on the hematopoietic stem cells (HSC) of 183 MDS patients as compared with the HSC of 17 healthy controls. The most significantly deregulated pathways in MDS include interferon signaling, thrombopoietin signaling and the Wnt pathway. Among the most significantly deregulated gene pathways in early MDS are immunodeficiency, apoptosis and chemokine signaling, whereas advanced MDS is characterized by deregulation of DNA damage response and checkpoint pathways. We have identified distinct gene expression profiles and deregulated gene pathways in patients with del(5q), trisomy 8 or â??7/del(7q). Patients with trisomy 8 are characteriz

ORGANISM(S): Homo sapiens

SUBMITTER: James Wainscoat 

PROVIDER: E-GEOD-19429 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress