DNA methylation distinguishes pathologically normal human tissues

ABSTRACT: Epigenetic control of gene transcription is critical for normal human development and cellular differentiation. While alterations of epigenetic marks such as DNA methylation have been linked to cancers and many other human diseases, interindividual epigenetic variation in normal tissues due to aging, environmental factors, or innate susceptibility are poorly characterized. The plasticity, tissue-specific nature, and variability of gene expression are related to epigenomic states that vary across individuals. Thus, population-based investigations are needed to further our understanding of the fundamental dynamics of normal individual epigenomes. We analyzed 217 non-pathologic human tissues from 10 anatomic sites at 1413 autosomal CpG loci associated with 773 genes to investigate tissue-spec

ORGANISM(S): Homo sapiens

SUBMITTER: Brock Christensen 

PROVIDER: E-GEOD-19434 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress