Hepatic Gene Expression in Rainbow Trout (Oncorhynchus mykiss) Exposed to Different Hydrocarbon Mixtures

ABSTRACT: Traditional biomarkers for hydrocarbon exposure are not induced by all petroleum substances. The objective of this study was to determine if exposure to a crude oil and different refined oils would generate a common hydrocarbon-specific response in gene expression profiles that could be used as generic biomarkers of hydrocarbon exposure. Juvenile rainbow trout (Oncorhynchus mykiss) were exposed to the water accommodated fraction (WAF) of either kerosene, gas oil, heavy fuel oil, or crude oil for 96 hours. Tissue was collected for RNA extraction and microarray analysis. Exposure to each WAF resulted in a different list of differentially regulated genes, with few genes in common across treatments. Exposure to crude oil WAF changed the expression of genes including CYP1A and GST with known ro

ORGANISM(S): Oncorhynchus mykiss

SUBMITTER: Sharon Hook 

PROVIDER: E-GEOD-19483 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress