Role of redox-dependent, flow-related regulation of AT1R expression in collateral growth impairment

ABSTRACT: Genomic analysis of control and collateral arteries was used to investigate mechanisms responsible for impaired collateral growth in the Spontaneously Hypertensive rat, an animal model of essential hypertension with increased oxidative and nitrosative stress and metabolic abnormalities. A fundamental difference was observed in the overall expression pattern in SHR vs WKY collaterals. Redox related genes with altered expression included cyba (the gene encoding p22phox), superoxide dismutase 3, and thioredoxin reductases 1 and 2. Cystatin C, hevin, angiotensinogen, and the angiotensin type 1b receptor (AT1bR) had altered collateral expression that was confirmed by RT-PCR. These molecules are known to have significant roles in other types of arterial remodeling. Of specific interest was

ORGANISM(S): Rattus norvegicus

SUBMITTER: Joseph Unthank 

PROVIDER: E-GEOD-19524 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress