Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Hiroshi Kogo
PROVIDER: E-GEOD-19532 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Journal of human genetics 20100326 5
Prophase I of male meiosis during early spermatogenesis involves dynamic chromosome segregation processes, including synapsis, meiotic recombination and cohesion. Genetic defects in the genes that participate in these processes consistently cause reproduction failure in mice. To identify candidate genes responsible for infertility in humans, we performed gene expression profiling of mouse spermatogenic cells undergoing meiotic prophase I. Cell fractions enriched in spermatogonia, leptotene/zygot ...[more]