Alpha-synuclein deficiency affects brain Foxp1 expression and ultrasonic vocalization

ABSTRACT: Alpha-synuclein is an abundant protein implicated in synaptic function and plasticity, but the molecular mechanism of its action is not understood. Missense mutations and gene duplication/triplication events result in Parkinson's disease, a neurodegenerative disorder of old age with impaired movement and emotion control. Here, we systematically investigated the striatal as well as the cerebellar transcriptome profile of alpha-synuclein-deficient mice via a genome-wide microarray survey in order to gain hypothesis-free molecular insights into the physiological function of alpha-synuclein. A genotype-dependent, specific and strong downregulation of forkhead box P1 (Foxp1) transcript levels was observed in all brain regions from postnatal age until old age and could be validated by qPCR. In v

ORGANISM(S): Mus musculus

SUBMITTER: Michael Walter 

PROVIDER: E-GEOD-19534 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress