Transcription profiling of rat identifies of a serum induced transcriptional signature associated with type 1 diabetes

ABSTRACT: Human type 1 diabetes (T1D) arises through autoimmunity towards the insulin-producing pancreatic β cells and is modeled by the BioBreeding (BB) rat. Factors associated with islet autoimmunity are dilute and difficult to directly measure in the periphery. Therefore, we previously utilized microarray-based bioassay where human T1D sera were used to induce a disease-specific gene expression signature in unrelated, healthy peripheral blood mononuclear cells (PBMC). Here we report that sera of both spontaneously diabetic BB DRlyp/lyp and diabetes inducible BB DR+/+ rats induce inflammatory signatures in healthy PBMC of non-diabetic Brown Norway (BN) rats, while allogeneic BN sera does not. Consistent with their common T1D susceptibility, transcriptional signatures of both BB sub-strains share

ORGANISM(S): Rattus norvegicus

SUBMITTER: Parthav Jailwala 

PROVIDER: E-GEOD-19537 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress