MicroRNA expression in rat lung receiving chemopreventive agents and attenuation of cigarette smoke-induced alterations

ABSTRACT: We previously showed that exposure of rats to environmental cigarette smoke (ECS) causes extensive downregulation of microRNA expression in the lung, resulting in overexpression of multiple genes and proteins. In the present study, we evaluated by microarray the expression of 484 microRNAs in the lung of rats receiving orally chemopreventive agents, including N-acetylcysteine, oltipraz, indole-3-carbinol, 5,6-benzoflavone and phenethyl isothiocyanate, or combinations thereof. Scatterplot, hierarchical cluster, and principal component analyses showed that none of the above chemopreventive regimens appreciably affected the baseline microRNA expression, while all of them attenuated ECS-induced alterations but to a variable extent. Thus, mirnome analysis provides a new tool for predicting b

ORGANISM(S): Rattus norvegicus

SUBMITTER: George Calin 

PROVIDER: E-GEOD-19540 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress