Imaging-guided microarray: Identifies molecular markers in the pathogenesis of Parkinson’s disease

ABSTRACT: The full complement of molecular pathways contributing to Parkinson’s disease (PD) pathogenesis remains unknown. Here, to address this issue, we began by using a high-resolution variant of functional magnetic resonance imaging (fMRI) to pinpoint brainstem regions differentially affected by, and resistant to, the disease. Then, relying on the imaging information as a guide, we profiled gene expression levels of postmortem brain samples and used a factorial statistical model to identify a disease related decrease in the expression of the polyamine enzyme spermidine/spermine N1-acetyltransferase 1 (SAT1). Next, a series of studies were performed to confirm the pathogenic relevance of this finding. First, to test for a causal link between polyamines and α-synuclein toxicity, we investigated

ORGANISM(S): Homo sapiens

SUBMITTER: scott small 

PROVIDER: E-GEOD-19587 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress