Endothelial transcriptional profiles of porcine coronary and iliac arteries passages 1 through 4

ABSTRACT: Atherosclerotic plaques tend to form in the major arteries at certain predictable locations. As these arteries vary in atherosusceptibility, inter-arterial differences in endothelial cell (EC) biology are of considerable interest. To explore the origin of differences observed between typical atheroprone and atheroresistant arteries, we used DNA microarrays to compare gene expression profiles of harvested porcine coronary (CECs) and iliac (IECs) artery ECs grown in static culture out to passage four. Fewer differences were observed between the transcriptional profiles of CECs and IECs in culture compared to in vivo, suggesting that most differences observed in vivo were due to distinct environmental cues in the two arteries. One-class significance of microarrays revealed that most in v

ORGANISM(S): Sus scrofa

SUBMITTER: Kelley Burridge 

PROVIDER: E-GEOD-19593 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress