MiRNA profiling in cervical carcinomas, low and high-grade intraepithelial cervical lesions and normal cervical tissues

ABSTRACT: Background. MicroRNAs (miRNAs) are short (~22 nt) non-coding regulatory RNAs that control gene expression at the translational level. Deregulation of miRNA expression has been discovered in a wide variety of tumours and it is now clear that they contribute to cancer development and progression. This prompted the development of miRNA-chips for cancer diagnosis or prognosis, opening a new door to understand carcinogenesis. Cervical cancer is one of the most common cancers in women worldwide. Therefore, there is a strong need for a non-invasive, fast and efficient method to diagnose the disease. We investigated miRNA expression profiles in cervical cancer using a microarray platform developed in house containing probes for mature miRNAs. Results. We have evaluated miRNA expression profiles of

ORGANISM(S): Homo sapiens

SUBMITTER: Patrícia Pereira 

PROVIDER: E-GEOD-19611 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress