Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Mouse sciatic nerve profile of CMT1A peripheral neuropathy model, caused by PMP22 overexpression

ABSTRACT: profiles of normal and diseased sciatic nerve of young adult mice Keywords: other

ORGANISM(S): Mus musculus

SUBMITTER: Anneloor ten Asbroek 

PROVIDER: E-GEOD-1962 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression profiling of sciatic nerve in a Charcot-Marie-Tooth disease type 1a mouse model.

ten Asbroek Anneloor L M A AL   Verhamme Camiel C   van Groenigen Marjon M   Wolterman Ruud R   de Kok-Nazaruk Maryla M MM   Baas Frank F  

Journal of neuroscience research 20050301 6

Expression profiling was performed on sciatic nerve of normal mice and of transgenic mice overexpressing the peripheral myelin protein 22 kDa (PMP22). These mice represent a model for the hereditary peripheral neuropathy Charcot-Marie Tooth type 1A. Comparison of the profiles reveals that the proteasomal degradation pathway and various signaling mechanisms are up-regulated in the diseased nerve. The down-regulated processes represent cell shape and adhesion as well as cellular activity and metab  ...[more]

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