MicroRNA profiling of cystic fibrosis intestinal disease in mice

ABSTRACT: Cystic fibrosis (CF) intestinal disease is characterized by alterations in processes such as proliferation and apoptosis which are known to be regulated in part by microRNA’s. Herein, we completed microRNA expression profiling of the intestinal tissue from the cystic fibrosis mouse model of cystic fibrosis transmembrane conductance regulator (Cftr) deficient mice (BALBc/J Cftrtm1UNC), relative to that of wildtype littermates, to determine whether changes in microRNA expression level are part of this phenotype. We identified 24 microRNA's to be significantly differentially expressed in tissue from CF mice compared to wildtype, with the higher expression in tissue from CF mice. These data were confirmed with real time PCR measurements. A comparison of the list of genes previously reported t

ORGANISM(S): Mus musculus

SUBMITTER: Christina Haston 

PROVIDER: E-GEOD-19621 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress