Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Compounds profiling on MCF7

ABSTRACT: The effects of several compounds on the MCF7 human adenocarcinoma mammary cell line were analysed by gene expression profiling. Tested compounds: HSP90 inhibitors: 17AAG (Tanespimycin), NVP-AUY922, NMS-E973 (cpd developed at NMS). CDK inhibitors: CDK-887 (cpd developed at NMS). Topoisomerase inhibitors: Doxorubicin, SN38 (active metabolite of Irinotecan). The MCF7 cell line was treated with the different compounds for 6 hours at a dose equal to 5 times the IC50. Untreated MCF7 cells were used as a control. Two replicates per treatment.

ORGANISM(S): Homo sapiens

SUBMITTER: Roberta Bosotti 

PROVIDER: E-GEOD-19638 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Discovery of drug mode of action and drug repositioning from transcriptional responses.

Iorio Francesco F   Bosotti Roberta R   Scacheri Emanuela E   Belcastro Vincenzo V   Mithbaokar Pratibha P   Ferriero Rosa R   Murino Loredana L   Tagliaferri Roberto R   Brunetti-Pierri Nicola N   Isacchi Antonella A   di Bernardo Diego D  

Proceedings of the National Academy of Sciences of the United States of America 20100802 33

A bottleneck in drug discovery is the identification of the molecular targets of a compound (mode of action, MoA) and of its off-target effects. Previous approaches to elucidate drug MoA include analysis of chemical structures, transcriptional responses following treatment, and text mining. Methods based on transcriptional responses require the least amount of information and can be quickly applied to new compounds. Available methods are inefficient and are not able to support network pharmacolo  ...[more]

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