Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Expression data from epithelial cells during the process of multistep pancreatic carcinogenesis

ABSTRACT: The host antitumor immunity changes drastically during carcinogenesis. Intraductal papillary-mucinous neoplasm (IPMN) of the pancreas is a precursor lesion of pancreatic cancer and progresses according to adenoma-carcinoma sequence. We found that the host antitumor immune reaction changes from an immune response to immune tolerance between intraductal papillary-mucinous adenoma (IPMA) and intraductal papillary-mucinous carcinoma (IPMC). In order to determine molecules affecting intraepithelial DC infiltration in IPMNs during multistep carcinogenesis, we examined the gene-expression profiles of entire transcripts of neoplastic cells at different stages. We collected normal and neoplastic epithelial cells from frozen tissue sections (normal main pancreatic duct, IPMA, IPMC, and invasive carcinoma originating in IPMN) by laser microdissection, extracted total RNA from them, and analyzed their gene expression profiles using Affymetrix microarrays.

ORGANISM(S): Homo sapiens

SUBMITTER: Nobuyoshi Hiraoka 

PROVIDER: E-GEOD-19650 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

CXCL17 and ICAM2 are associated with a potential anti-tumor immune response in early intraepithelial stages of human pancreatic carcinogenesis.

Hiraoka Nobuyoshi N   Yamazaki-Itoh Rie R   Ino Yoshinori Y   Mizuguchi Yasunori Y   Yamada Tesshi T   Hirohashi Setsuo S   Kanai Yae Y  

Gastroenterology 20101016 1

<h4>Background & aims</h4>Anti-tumor immunity changes over the course of tumor progression; it is not clear how or when the developing tumor overcomes immune surveillance. Intraductal papillary mucinous neoplasm (IPMN) is an intraepithelial precursor lesion of pancreatic cancer that progresses from adenoma to carcinoma. We investigated when and how the human anti-tumor immune reaction changes during pancreatic tumor development.<h4>Methods</h4>Using immunohistochemical analysis of cells isolated  ...[more]

Similar Datasets

Unknown Expression data from epithelial cells during the process of multistep pancreatic carcinogenesis
2010-12-23 | GSE19650 | GEO
Transcriptomics miRNA expression profiles in Pancreatic Cystic tumours and Pancreatic Cancer
2011-05-18 | E-GEOD-29352 | biostudies-arrayexpress
Unknown Visium Spatial Transcriptomics expression profiles from IPMN samples of the pancreas
2023-06-07 | GSE233293 | GEO
Unknown miRNA expression profiles in Pancreatic Cystic tumours and Pancreatic Cancer
2011-05-18 | GSE29352 | GEO
Proteomics Quantitative Proteomic Analysis of Pancreatic Cyst Fluid Proteins Associated with Malignancy in Intraductal Papillary Mucinous Neoplasms
2018-05-01 | PXD008302 | Pride
Unknown Nuclear GSK-3β and Oncogenic KRas Promote Expansion of Terminal Duct Cells and the Development of Intraductal Papillary Mucinous Neoplasm
2022-03-22 | GSE153548 | GEO
Transcriptomics Brg1 promotes both tumor suppressive and oncogenic activities at distinct stages of Pancreatic cancer formation
2015-07-29 | E-GEOD-65315 | biostudies-arrayexpress
Proteomics Kinase activities in pancreatic ductal adenocarcinoma with prognostic and therapeutic avenues
2024-04-23 | PXD043111 | Pride
Unknown Transcriptome analysis of Arid1a-deficient IPMN and Brg1-deficient IPMN
2018-03-31 | GSE96926 | GEO
Proteomics Comprehensive Proteomic Characterization of Human Pancreatic Cyst Fluid from Intraductal Papillary Mucinous Neoplasm by LC-MS/MS
2017-08-22 | PXD005671 | Pride