Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Genetic Influences on Asthma Susceptibility in Developing Lung

ABSTRACT: Whole transcriptome assay of whole lung of rat from 3 genetic strains (Lewis, Fisher, Brown Norway) at 3 postnatal time points (postnatal days 1, 7, 14). Total RNA obtained from whole lung of rat from 3 genetic strains and 3 postnatal time points in (mainly) quadruplicate measurements per strain and time point.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Alvin Kho 

PROVIDER: E-GEOD-19666 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genetic influences on asthma susceptibility in the developing lung.

Carpe Nicole N   Mandeville Isabel I   Ribeiro Leslie L   Ponton Andre A   Martin James G JG   Kho Alvin T AT   Chu Jen-Hwa JH   Tantisira Kelan K   Weiss Scott T ST   Raby Benjamin A BA   Kaplan Feige F  

American journal of respiratory cell and molecular biology 20100129 6

Asthma is the leading serious pediatric chronic illness in the United States, affecting 7.1 million children. The prevalence of asthma in children under 4 years of age has increased dramatically in the last 2 decades. Existing evidence suggests that this increase in prevalence derives from early environmental exposures acting on a pre-existing asthma-susceptible genotype. We studied the origins of asthma susceptibility in developing lung in rat strains that model the distinct phenotypes of airwa  ...[more]