P19 cells+LIN28_RA-differentiated_Day 4

ABSTRACT: LIN28 is an RNA-binding protein expressed in many developing tissues. It can block let-7 microRNA processing and help promote pluripotency. We observe LIN28 expression in the developing neural tube, colocalizing with SOX2, suggesting a role in neural development. To better understand its normal developmental function, we investigated LIN28 activity during neurogliogenesis in vitro where the succession of neuronal to glial cell fates occurs as it does in vivo. LIN28 expression was high in undifferentiated cells, and was down-regulated rapidly upon differentiation. Constitutive LIN28 expression caused a complete block of gliogenesis and an increase in neurogenesis. LIN28 expression was compatible with neuronal differentiation and did not increase proliferation. LIN28 caused significant chang

ORGANISM(S): Mus musculus

SUBMITTER: Vivian Lee 

PROVIDER: E-GEOD-19705 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress