Alu sequences in undifferentiated human embryonic stem cells display high levels of A-to-I RNA editing

ABSTRACT: Adenosine to Inosine (A-to-I) RNA editing is a site-specific modification of RNA transcripts, catalyzed by members of the ADAR (Adenosine Deaminase Acting on RNA) protein family. RNA editing occurs in human RNA in thousands of different sites. Some of the sites are located in protein-coding regions but the majority is found in non-coding regions, such as 3’UTRs, 5’UTRs and introns - mainly in Alu elements. While editing is found in all tissues, the highest levels of editing are found in the brain. It was shown that editing levels within protein-coding regions are increased during embryogenesis and after birth and that RNA editing is crucial for organism viability as well as for normal development. In this study we characterized the A-to-I RNA editing phenomenon during neuronal and spon

ORGANISM(S): Homo sapiens

SUBMITTER: Gideon Rechavi 

PROVIDER: E-GEOD-19719 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress