Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Genes regulated by miR-145

ABSTRACT: We used Affymetrix HG U133 Plus 2.0 GeneChips to compare the transcriptome of miR-145-overexpressing MDA-MB-231 cells against negative control miRNA precursor-transfected cells. MDA-MB-231 cells were transfected with pre-miR-145 or a negative control pre-miRNA, and subsequently total RNA was collected and processed for analysis using Affymetrix microarrays. Three independent replicates were prepared for each comparison group.

ORGANISM(S): Homo sapiens

SUBMITTER: George Yip 

PROVIDER: E-GEOD-19737 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness.

Götte M M   Mohr C C   Koo C-Y CY   Stock C C   Vaske A-K AK   Viola M M   Ibrahim S A SA   Peddibhotla S S   Teng Y H-F YH   Low J-Y JY   Ebnet K K   Kiesel L L   Yip G W GW  

Oncogene 20100906 50

Micro RNAs are small non-coding RNAs, which regulate fundamental cellular and developmental processes at the transcriptional and translational level. In breast cancer, miR-145 expression is downregulated compared with healthy control tissue. As several predicted targets of miR-145 potentially regulate cell motility, we aimed at investigating a potential role for miR-145 in breast cancer cell motility and invasiveness. Assisted by Affymetrix array technology, we demonstrate that overexpression of  ...[more]

Similar Datasets

Unknown Genes regulated by miR-145
2010-09-07 | GSE19737 | GEO
Transcriptomics Genes regulated by HS3ST2
2016-08-15 | E-GEOD-49962 | biostudies-arrayexpress
Transcriptomics Genes regulated by SDC1
2013-08-01 | E-GEOD-23362 | biostudies-arrayexpress
Unknown Argonaute 2 drives miR-145-dependent gene expression program in breast cancer cells
2018-12-18 | GSE120896 | GEO
Unknown miRNAs were significantly regulated by myocardin and ERα
2014-10-01 | GSE44139 | GEO
Transcriptomics miRNAs were significantly regulated by myocardin and ERM-NM-1
2014-10-01 | E-GEOD-44139 | biostudies-arrayexpress
Transcriptomics miR-145 transfected PC3 cells
2014-06-15 | E-GEOD-58295 | biostudies-arrayexpress
Unknown Breast cancer MCF-7 Cells and MDA-MB-435 cells: pre-miR-125b Transfected cells vs. pre-control transfected cells
2010-06-25 | GSE22546 | GEO
Unknown Breast cancer MCF-7 cells and MDA-MB-231 cells: LNA-antimiR-21 transfected cells vs. LNA-control transfected cells
2010-03-05 | GSE20627 | GEO
Unknown Gene expression profiling of MDA-MB-231 cells transfected with hsa-miR-205-5p and hsa-miR-214-3p compared to scrambled miRNA precursors
2020-05-31 | GSE148847 | GEO