Whole-genome analysis reveals active heat shock factor binding sites are mostly associated with non-heat shock genes
Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Zak Razak
PROVIDER: E-GEOD-19746 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Whole-genome analysis reveals that active heat shock factor binding sites are mostly associated with non-heat shock genes in Drosophila melanogaster.
Gonsalves Sarah E SE Moses Alan M AM Razak Zak Z Robert Francois F Westwood J Timothy JT
PloS one 20110114 1
During heat shock (HS) and other stresses, HS gene transcription in eukaryotes is up-regulated by the transcription factor heat shock factor (HSF). While the identities of the major HS genes have been known for more than 30 years, it has been suspected that HSF binds to numerous other genes and potentially regulates their transcription. In this study, we have used a chromatin immunoprecipitation and microarray (ChIP-chip) approach to identify 434 regions in the Drosophila genome that are bound b ...[more]
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