Adrenocortical Carcinoma Gene Expression Profiling [Affymetrix]

ABSTRACT: Background: Adrenocortical carcinoma (ACC) is associated with poor survival rates. The objective of the study was to analyze ACC gene expression profiling data prognostic biomarkers and novel therapeutic targets. Methods: 44 ACC and 4 normal adrenal glands were profiled on Affymetrix U133 Plus 2 expression microarrays and pathway and transcriptional enrichment analysis performed. Protein levels were determined by western blot. Drug efficacy was assessed against ACC cell lines. Previously published expression datasets were analyzed as validation data sets. Results: Pathway enrichment analysis identified marked dysregulation of cyclin-dependent kinases and mitosis. Over-expression of PTTG1, which encodes securin, a negative regulator of p53, was identified as a marker of poor survival.

ORGANISM(S): Homo sapiens

SUBMITTER: Kimberly Bussey 

PROVIDER: E-GEOD-19750 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress