Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression Data from Bone Marrow Progenitor-Derived Adipocytes, White Adipocytes and Brown Adipocytes.

ABSTRACT: We have identified a population of adipocytes in fat tissue that arise from bone marrow-derived progenitor cells. We used microarrays to compare the global gene expression patterns of the bone marrow progenitor-derived adipocytes as well as conventional white and brown adipocytes to evaluate the relationship between these adipocyte subpopulations. Gonadal fat tissue (for white adipocytes) and intrascapular fat tissue (for brown adipocytes) was digested with collagenase and adipocytes were recovered by centrifugation/flotation. Bone marrow derived adipocytes were isolated from the adipocyte fraction of gonadal fat tissue from mice receiving bone marrow tranplants from donors expressing either green fluorescent protein (GFP) or beta-galactosidase (LacZ) by flow cytometry.

ORGANISM(S): Mus musculus

SUBMITTER: Dwight Klemm 

PROVIDER: E-GEOD-19757 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

De novo generation of white adipocytes from the myeloid lineage via mesenchymal intermediates is age, adipose depot, and gender specific.

Majka Susan M SM   Fox Keith E KE   Psilas John C JC   Helm Karen M KM   Childs Christine R CR   Acosta Alistaire S AS   Janssen Rachel C RC   Friedman Jacob E JE   Woessner Brian T BT   Shade Theodore R TR   Varella-Garcia Marileila M   Klemm Dwight J DJ  

Proceedings of the National Academy of Sciences of the United States of America 20100802 33

It is generally assumed that white adipocytes arise from resident adipose tissue mesenchymal progenitor cells. We challenge this paradigm by defining a hematopoietic origin for both the de novo development of a subset of white adipocytes in adults and a previously uncharacterized adipose tissue resident mesenchymal progenitor population. Lineage and cytogenetic analysis revealed that bone marrow progenitor (BMP)-derived adipocytes and adipocyte progenitors arise from hematopoietic cells via the  ...[more]

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