Gene expression profiling of hypertensive and hypotensive mice

ABSTRACT: Hypertension is a condition with major cardiovascular and renal complications, affecting nearly a billion patients worldwide. Few validated gene targets are available for pharmacological intervention, so there is a need to identify new biological pathways regulating blood pressure and containing novel targets for treatment. The genetically hypertensive “blood pressure high” (BPH), normotensive “blood pressure normal” (BPN), and hypotensive "blood pressure low" (BPL) inbred mouse strains are an ideal system to study differences in gene expression patterns that may represent such biological pathways. We profiled gene expression in liver, heart, kidney, and aorta from BPH, BPN, and BPL mice and determined which biological processes are enriched in observed organ-specific gene signat

ORGANISM(S): Mus musculus

SUBMITTER: Mette Peters 

PROVIDER: E-GEOD-19817 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress