Expanding the substantial interactome of NEMO using protein microarrays

ABSTRACT: Signal transduction by the NF-kappaB pathway is a key regulator of a host of cellular responses to extracellular and intracellular messages. The NEMO adaptor protein lies at the top of this pathway and serves as a molecular conduit, connecting signals transmitted from upstream sensors to the downstream NF-kappaB transcription factor and subsequent gene activation. The position of NEMO within this pathway makes it an attractive target from which to search for new proteins that link NF-kappaB signaling to additional pathways and upstream effectors. In this work, we have used protein microarrays to identify novel NEMO interactors. A total of 112 protein interactors were identified, with the most statistically significant hit being the canonical NEMO interactor IKKbeta, with IKKalpha also bein

ORGANISM(S): Homo sapiens

SUBMITTER: Beau Fenner 

PROVIDER: E-GEOD-19841 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress