Human gliomatosis cerebri vs. non-neoplastic adult brain tissue

ABSTRACT: We report the results of a molecular study in thirty-seven cases of gliomatosis cerebri, correlating these results with prognosis. The well-known prognostic factors of gliomas, i.e., age, KPS, histology (Grade 2 vs. 3), or contrast enhancement, was predictive of response or outcome only in a percentage of patients but not in all patients. We identified an 8 miRNA signature able to predict patient prognosis with microarray gene expression profiling. The 8 gene features were used to built a prediction method able to distinguish patients with good prognosis (more likely to be responsive to therapy) from patients with a poor prognosis (less likely to be responsive to therapy). Keywords: miRNA expression profile Fifty-nine patients, between 12- and 73-years-old, with clinical signs of increa

ORGANISM(S): Homo sapiens

SUBMITTER: Oscar D'Urso 

PROVIDER: E-GEOD-19870 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress