Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa (Illumina)

ABSTRACT: In higher eukaryotes, histone methylation is involved in the maintenance of cellular identity during somatic development. During spermatogenesis, Since most nucleosomes are replaced by protamines during spermatogenesis . Iit is therefore unclear whether if histone modifications function in paternal transmission of epigenetic information. Here we show that H3K4 di-methylation (H3K4me2) and H3K27 tri-methylation (H3K27me3), two modifications important for Trithorax and Polycomb-mediated gene regulation, display methylation-specific distributions at regulatory regions in human spermatozoa. H3K4 dimethylation H3K4me2-marksed promoters of genes relevant control gene functions in spermatogenesis and cellular homeostasis suggesting that this mark reflects germline transcription. In contrast, H3K2

ORGANISM(S): Homo sapiens

SUBMITTER: Antoine Peters 

PROVIDER: E-GEOD-19889 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress