A mesoderm-derived mesenchymal stem/stromal cells (MSC) precursor: time course experiment

ABSTRACT: Mesenchymal stem/stromal cells (MSCs) are multipotent cells that can differentiate into a variety of cell types forming connective tissue and skeleton, and are essential participants in the development of all organs. However, MSC precursors remain largely unknown. In human embryonic stem cells (hESCs) directed to mesendodermal differentiation through coculture with OP9 stromal cells, we identified a population of mesodermal cells by surface expression of apelin receptor (APLNR1). APLNR+ cells were enriched with precursors generating compact spheroid colonies in semisolid suspension culture. Being formed by single cells, these colonies consisted of a uniform population of mesenchymal cells with a transcriptional profile representative of embryonic mesenchyme originating from lateral plate/e

ORGANISM(S): Homo sapiens

SUBMITTER: Igor Slukvin 

PROVIDER: E-GEOD-20045 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress