Transcription profiling of human platelets from patients with essential thrombocythemia

ABSTRACT: Human blood platelets have important, regulatory functions in diverse hemostatic and pathological disorders, including vascular remodeling, inflammation, and wound repair. Microarray analysis was used to study the molecular basis of essential thrombocythemia, a myeloproliferative disorder with quantitative and qualitative platelet defects associated with cardiovascular and thrombohemorrhagic symptoms, not infrequently neurological. A platelet-expressed gene (HSD17B3) encoding type 3 17beta-hydroxysteroid dehydrogenase (previously characterized as a testis-specific enzyme catalyzing the final step in gonadal synthesis of testosterone) was selectively down-regulated in ET platelets, with reciprocal induction of the type 12 enzyme (HSD17B12). Functional 17beta-HSD3 activity corresponding to a

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER: Wadie Bahou 

PROVIDER: E-GEOD-2006 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress