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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from p27delta51 MEFs cells in quiescence

ABSTRACT: Low levels of the cell cycle regulator p27Kip1 are associated with a worse outcome in many tumor types. We report here a new regulatory role of p27Kip1 as a transcriptional regulator. In association with transcriptional repressors such as p130, E2F4 and HDACs, p27 binds to promoters of multiple genes leading to their repression. The p27Kip1-target genes participate in RNA processing, translation, respiration and cell cycle. Remarkably, p27Kip1-target genes are over-expressed in different human tumors in tight association with a poor clinical prognosis. We also observed a clear correlation between low levels of p27Kip1 and over-expression of p27Kip1-target genes in tumors. Overall, our findings indicate new tumor suppressor roles of p27Kip1 as a transcriptional regulator of genes relevant for oncogenesis. Samples from MEFs p27delta51 and p27WT cells used as control were analyzed

ORGANISM(S): Mus musculus

SUBMITTER: oriol bachs

PROVIDER: E-GEOD-20064 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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