Aberrantly microRNA profiling in cancerous hepatocytes versus normal primary hepatocytes

ABSTRACT: MicroRNAs is a rapidly expanding area expected to change the way in which diseases will be diagnosed, treated and monitored in the future. Hepatocellular carcinoma (HCC) shows a rising incidence with high mortality but lack of effective targeted therapies. We identified the aberrantly expressed miRNAs involved in HCC through the comparison of miRNA expression profiling in cancerous hepatocytes with that in normal primary human hepatocytes and found 37 dysregulated miRNAs in HCC. These aberrantly expressed miRNAs may provide insights into pathogenesis of HCC and thus may be used for diagnosis and therapy. Over the past few years, though several studies have uncovered aberrant miRNA expression profiles in HCC compared with matched nonmalignant tissues, the overlap of deregulated miRNAs from

ORGANISM(S): Homo sapiens

SUBMITTER: Xing-Xing He 

PROVIDER: E-GEOD-20077 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress