Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Cross species comparison of expression patterns


ABSTRACT: Comparison of expression in liver samples of human, chimp, orang and rhesus, by using a novel multi-species cDNA array

ORGANISM(S): Homo sapiens

SUBMITTER: Mark Gerstein 

PROVIDER: E-GEOD-2009 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Multi-species microarrays reveal the effect of sequence divergence on gene expression profiles.

Gilad Yoav Y   Rifkin Scott A SA   Bertone Paul P   Gerstein Mark M   White Kevin P KP  

Genome research 20050501 5


Interspecies comparisons of gene expression levels will increase our understanding of the evolution of transcriptional mechanisms and help to identify targets of natural selection. This approach holds particular promise for apes, as many human-specific adaptations are thought to result from differences in gene expression rather than in coding sequence. To date, however, all studies directly comparing interspecies gene expression have been performed on single-species arrays, so that it has been i  ...[more]

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