Structural Variation of the Mouse Natural Killer Gene Complex as Determined by High Resolution Array-based CGH Profiling

ABSTRACT: We used aCGH data for detailed analysis of the natural killer gene complex (NKC) of multiple inbred strains, providing insight both into aCGH analysis of polymorphic gene clusters as well as structural information on the NKC itself. By unsupervised clustering analysis, the aCGH data can be precisely correlated with overall genome structural variation of the NKC as detected by RFLP variants in retrospective and prospective analyses. On a high resolution level, aCGH could be used to detect a small deletion within an NKC gene that is confined to only one mouse strain examined out of 22. The NKC region on mouse chromosome 6 is known to be an area with structural variation based on studies which reveal restriction fragment length polymorphic (RFLP) variants among inbred mouse strains. To ver

ORGANISM(S): Mus musculus

SUBMITTER: Darryl Higuchi 

PROVIDER: E-GEOD-20090 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress