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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptional analysis of time course in response to HY-PDT on human nasopharyngeal carcinoma cell line CNE-2

ABSTRACT: Analysis of photodynamic therapy with hypericin of nasopharyngeal carcinoma cells CNE-2 in different time-points at gene expression level. The hypothesis tested in the present study was that HY-PDT could induce apoptosis on CNE-2 cells via intrinsic pathways. Results provide important information of the response of apoptosis, such as specific oxidative stress genes, mitochondrial related genes, cell cycle related genes, etc. Total RNAs were isolated from the cultured cells treatment with 20 μg/ml HY and irradiation then cultured in dark for 0, 2, 6, 12, 20 h respectively compared to cells treatment with 20 μg/ml HY only then cultured in dark for 20 h.

ORGANISM(S): Homo sapiens

SUBMITTER: shu yang

PROVIDER: E-GEOD-20134 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptional analysis of time course in response to HY-PDT on human nasopharyngeal carcinoma cell line CNE-2

Project description:Analysis of photodynamic therapy with hypericin of nasopharyngeal carcinoma cells CNE-2 in different time-points at gene expression level. The hypothesis tested in the present study was that HY-PDT could induce apoptosis on CNE-2 cells via intrinsic pathways. Results provide important information of the response of apoptosis, such as specific oxidative stress genes, mitochondrial related genes, cell cycle related genes, etc.

2011-01-28 | GSE20134 | GEO

Human SCC-13 Cells: Control vs. Resitant populations to photodynamic therapy (PDT)

Project description:aCGH of control cells not subjected to PDT (Parental) and cells subjected to 5 or 10 sequential PDT treatments (5ºG and 10ºG, respectively).

2013-09-06 | GSE50602 | GEO

Human SCC-13 Cells: Control vs. Resitant populations to photodynamic therapy (PDT)

Project description:aCGH of control cells not subjected to PDT (Parental) and cells subjected to 5 or 10 sequential PDT treatments (5M-BM-:G and 10M-BM-:G, respectively). Three-condition experiment, cultures of SCC-13 cells not subjected to PDT (Parental) vs 5M-BM-:G and 10M-BM-:G generations of resistant cells.

2013-09-06 | E-GEOD-50602 | biostudies-arrayexpress

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Project description:The response of tumors to PDT treatment is expected to provide information on effects of oxygen depletion, induced apoptosis, induction of an inflammatory response and induction of an ani-tumor immune response. Experiment Overall Design: NCI-H69 human SCLC xenografts were induced in SCID mice. Three pairs of xenograft tumors, PDT treated and untreated controls, were harvested four hours after PDT treatment. RNA was isolated and prepared for hybridization to human Affymetrix GeneChip arrays.

2008-06-16 | E-GEOD-8920 | biostudies-arrayexpress

Resitant populations to photodynamic therapy (PDT) of squamous cell carcinoma cells (SCC-13)

Project description:aCGH of control cells not subjected to PDT (Parental), cells subjected to 10 sequential PDT treatments (10G) and 10G cells inoculated in immunosuppressed mice; the induced tumors were subcultured by explants to obtain a cell resistant population called 10GT

2021-07-21 | GSE180325 | GEO

Homo sapiens

Project description:Transcriptional analysis of time course in response to HY-PDT on human nasopharyngeal carcinoma cell line CNE-2

| PRJNA125665 | ENA

Early expression data of H69 xenograft tumors following PDT treatment.

2007-11-01 | GSE8920 | GEO

Low Dose PDT - Human Cells

Project description:Human tumour cell lines PC3, DU145, U87 and U373 (prostate carcinoma and glioblastoma) were treated with photosensitizers 5-aminolaevulinic acid (5-ALA) or photofrin. Then, the cells were irradiated sublethally with 635 nm laser light.<br>After photodynamic therapy, the cells were grown at 37°C for 4 or 24 hours in the dark until extraction of total RNA and expression profiling.

2011-06-26 | E-MEXP-3020 | biostudies-arrayexpress

Growth factor stimulation of cardiomyocytes induces changes in the transcriptional contents of secreted exosomes

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Project description:Tumors were induced in C57BL/6 mice by subcutaneous injection of murine prostate carcinoma cell line TRAMP-C2. Tumor-bearing mice were narcotized, injected with photosensitizer 5-aminolaevulinic acid (5-ALA), shaven at their back, and 3-4 h later the whole tumor area was irradiated perpendicular (under anesthesia) through the intact skin using a 635 nm laser (75 or 100 J/cmM-2 at 200 mW/cmM-2). After treatment the mice were kept in the dark, then the tumor was excised and total RNA was extracted for expression profiling.

2011-06-25 | E-MEXP-3017 | biostudies-arrayexpress

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