Microarray studies on effect of Pneumocystis carinii infection on global gene expression in alveolar macrophages
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Chao-Hung Lee
PROVIDER: E-GEOD-20149 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Microarray studies on effects of Pneumocystis carinii infection on global gene expression in alveolar macrophages.
Cheng Bi-Hua BH Liu Yunlong Y Xuei Xiaoling X Liao Chung-Ping CP Lu Debao D Lasbury Mark E ME Durant Pamela J PJ Lee Chao-Hung CH
BMC microbiology 20100408
<h4>Background</h4>Pneumocystis pneumonia is a common opportunistic disease in AIDS patients. The alveolar macrophage is an important effector cell in the clearance of Pneumocystis organisms by phagocytosis. However, both the number and phagocytic activity of alveolar macrophages are decreased in Pneumocystis infected hosts. To understand how Pneumocystis inactivates alveolar macrophages, Affymetrix GeneChip RG-U34A DNA microarrays were used to study the difference in global gene expression in a ...[more]
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